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Prednisolone and other corticosteroids can mask signs of infection and impair the body’s natural immune response to infection. Patients on corticosteroids are more susceptible to infections and can develop more serious infections than healthy individuals. For instance.chickenpox and measles viruses can produce serious and even fatal illnesses in patients on high doses of prednisolone. Live virus vaccines.such as smallpox vaccine.should be avoided in patients taking high doses of prednisolone.since even vaccine viruses may cause disease in patients taking prednisolone. Some infectious organisms.such as tuberculosis (TB) and malaria.can remain dormant in a patient for years. Prednisolone and other corticosteroids can reactivate dormant infections in these patients and cause serious illnesses. Patients with dormant TB may require anti-TB medications while undergoing prolonged corticosteroid treatment.
Combining aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids increases the risk of gastrointestinal side effects.
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