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To support the use of the prolonged-release tabletsthe company conducted studies to show that the immediateand prolonged-release tablets both had adequate drug levelsand the same effect on the viral load in the bodyStudies were also done to show successful switching from immediate-release tabletstwice daily to prolonged-release tabletsonce daily.

Viramune should not be used as the sole active antiretroviralas monotherapy with any antiretroviral has shown to result in viral resistance.

Because of the risk of increased exposure to Viramunecaution should be exercised if the medicinal products are given concomitantly and patients should be monitored closely.

Results of in vitro studies showed a weak antagonism of nevirapine by adefovirsee section 5.1this has not been confirmed in clinical trials and reduced efficacy is not expectedAdefovir did not influence any of the common CYP isoforms known to be involved in human drug metabolism and is excreted renallyNo clinically relevant drug-drug interaction is expected.

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