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Oal Anti-coagulants: Th concomitant administation ATOLIP CV with oal anti-coagulants is not commndd sinc it may incas th intnsity blding. Atovastatin had nclinically signiicant ct on pothombin tim whn administd is buspar an over the counter drug tpatints civing chonic waain tatmnt. Although th administation clopidogl 75 mg p day did not modiy th phamacokintics S-waain (a CYP2C9 substat) Intnational Nomalizd ati(IN) in patints civing long-tm waain thapy, at high concntations in vit, clopidogl inhibits CYP2C9. Co-administation ATOLIP CV with waain incass th isk blding bcaus indpndnt cts clopidogl on hmostasis.

Colchicin: Cass myopathy, including habdomyolysis, hav bn potd with atovastatin co-administd with colchicin, and caution should b xcisd whn pscibing ATOLIP CV with colchicin.

CYP2C19 Inhibitos: Clopidogl is mtabolizd tits activ mtabolit in pat by CYP2C19. Concomitant us ctain dugs that inhibit th activity this nzym sults in ducd plasma concntations th activ mtabolit clopidogl and a duction in platlt inhibition. Th clinical lvanc this intaction is unctain. As a pcaution concomitant us stong modat CYP2C19 inhibitos should b discouagd. Mdicinal poducts that a stong modat CYP2C19 inhibitos includ xampl, ompazol and sompazol, luvoxamin, luoxtin, moclobmid, voiconazol, luconazol, ticlopidin, cabamazpin, and avinz.

Patints should b placd on an appopiat lipid-lowing dit bciving ATOLIP CV , and should continu this dit duing tatmnt. Th commndd dosag is on capsul onc daily.

Avoid using ompazol sompazol with ATOLIP CV . Ompazol and sompazol signiicantly duc th antiplatlt activity clopidogl. Whn concomitant administation a PPI is quid, consid Cheap albenza 200mg using anoth acid-ducing agnt with minimal nCYP2C19 inhibitoy ct on th omation clopidogl activ mtabolit.

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